Neutrophil Extracellular Traps Induce Trypsin Activation

MeSH: P-selektin - Finto

1997 Oct 15;159(8):3929-39. 2011-09-01 P-Selectin P-selektin Engelsk definition. Cell adhesion molecule and CD antigen that mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells. The R-PLEX platform offers matched sets of antibodies and calibrators for a wide menu of biomarkers. The R-PLEX Human P-Selectin Antibody Set can be used with other MSD components (see "Recommended Components" tab below) to build assays that measure P-Selectin.

P selectin

P-Selectin, also known as CD62P, GMP-140, PADGEM, and LECAM-3, is a transmembrane adhesion protein that is upregulated on activated platelets and vascular endothelial cells. It binds to hematopoietic cell PSGL-1/CD162 with highly clustered O-linked sialyl Lewis-x (sLex ) tetrasaccharides and sulfated tyrosine, as well as to heparin sulfate, Versican, and CD42b/GPIb alpha. P-selectin is a cell adhesion molecule of platelets and endothelial cells stored in secretory granules and rapidly expressed on the plasma membrane on activation.10-13 After expression on the cell surface both endothelial and platelet P-selectin mediate leukocyte adhesion.14 Whereas endothelial P-selectin has clearly been shown to be involved in leukocyte and platelet rolling,15,16 the role of P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets.

Rectenwald JE(1), Myers DD Jr, Hawley AE, Longo C, Henke PK, Guire KE, Schmaier AH, Wakefield TW. Author information: (1)Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA. jrectenw@umich.edu 1993-04-01 2021-01-12 SELP (Selectin P) is a Protein Coding gene.

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engelska. Antigen, CD62P. Antigens, CD62P.

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It is the primary ligand for the P-Selectin glycoprotein ligand-1 and is important in the initial recruitment of leukocytes and platelets during inflammation and injury. P-selectin deficiency decreases tissue stiffness in Rip1-Tag2 mouse insulinomas. We previously reported that P-selectin deletion significantly inhibits insulinoma growth in Rip1-Tag2 mice [] and that tumor tissue stiffness increases in conjunction with insulinoma progression (Figure 1).To investigate the effects of P-selectin on insulinoma tissue stiffness, we subjected Rip1-Tag2 and Rip1-Tag2 2020-03-01 In this video we discuss the three different types of selectins and their involvement in the immune system. P-selectin plasma from blood samples taken from the subjects of the study was analyzed and compared. A set of P-selectin was purchased from Randox Laboratories Limited (UK). The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from … "P-Selectin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. 2 days ago P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.

Free. Antigensymbol, P-Selectin. Antikroppstyp, Primary. Klonalitet, Monoclonal. Konjugation, Unconjugated. Värd, Mouse. Isotyp, IgG1.
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P-selectin exponeras och kan binda till PSGL-1 (p-selectin glycoproteinligand 1) på monocyter, leukocyter och endotelceller. Detta gör att trombocyten kan fästa av J Grossman — samma sätt betydelsen av P-selectin-glykoproteinligand-1 (PSGL-1) och antikroppar mot denna ytmolekyl förhindrade adhesionen av A. phagocytophilum till (CK-MB); Flödescytometri-analys av VASP-P; ELISA-bestämningar av ET-1 och vWF; P-selectin- och cAMP-bestämningar; Inflammatoriska medlarnivåer Chai CM, Almen T, Aspelin P, Baath L. Effects on erythrocyte aggregation and Thorlacius H. CC chemokines induce P-selectin-dependent neutrophil rolling LPS gör dock inte att trombocyter aggregeras eller att trombocyter uttrycker sin normala aktiveringsmarkör P-selectin (vilket har gjort att forskargrupper trott att as IL-4, IL-6, IL-8, and IL-13 from human mast cells/basophils, as well as inhibition of the expression of the adhesion molecule P-selectin on endothelial cells. as well as inhibition of the expression of the adhesion molecule P-selectin on endothelial cells. Dessa omfattar hämning av frisättning av proinflammatoriska P-selectin on endothelial cells.
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title = "P-Selectin and P-Selectin Glycoprotein Ligand 1 Mediate Rolling of Activated CD8+ T Cells in Inflamed Colonic Venules.",. abstract = "BACKGROUND:: Detect Mouse P Selectin/SELP with <5pg/ml sensitivity. Format: 96-well plate with removable strips.

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Anaplasma phagocytophilum - CORE

It binds to hematopoietic cell PSGL-1/CD162 with highly clustered O-linked sialyl Lewis-x (sLex ) tetrasaccharides and sulfated tyrosine, as well as to heparin sulfate The adhesion molecule P-selectin (CD62P) is of interest because of its role in modulating interactions between blood cells and the endothelium, and also because of the possible use of the soluble form as a plasma predictor of adverse cardiovascular events.